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From Houston:

Take I-45 S toward Galveston
Take Exit 26 toward Bay Area Blvd
Take the W Bay Area Blvd ramp towards U of H/Clear Lake
Turn right on Bay Area Blvd
Turn right at N Texas Ave
Arrive at 333 N Texas Ave on the right

From Pearland:

Head N on S Main St toward W Broadway St/Farm to Market 518 W
Take the 1st right onto E Broadway St/Farm to Market 518 E
Turn left at Farm to Market 528 E
Continue onto Nasa Pkwy/Nasa Rd 1
Turn left at N Texas Ave
Arrive at 333 N Texas Ave on the left

From Friendswood:

Head southeast on Farm to Market 518 E/S Friendswood Dr toward E Willowick Ave
Turn left on Farm to Market 528 E
Continue onto Nasa Pkwy/Nasa Rd 1
Turn left at N Texas Ave
Arrive at 333 N Texas Ave on the left

From Pasadena:

Take S Shave St toward Old Galveston Rd/Hwy 3
Turn left at Old Galveston Rd/Hwy 3
Turn right at Medical Center Blvd
Turn left at N Texas Ave
Arrive at 333 N Texas Ave on the right

From Galveston/League City/Texas City/Dickinson:

Take 1-45 N toward Houston
Take Exit 25 toward Nasa 1/Farm to Market Rd 528
Turn right at Nasa Pkwy/Nasa Rd 1
Turn left at N Texas Ave
Arrive at 333 N Texas Ave on the left